由环氧锂制备醇

p>To a solution of(1R,2S)-1-(4,5-diphenyloxazol-2-yl)-1,2-epoxycyclohexane (20 g) and CuBr (3.0g) in tetrahydrofuran (400 ml) was dropwise added a solution of3-methoxybenzylmagnesium chloride [prepared from 3-methoxy-benzylchloride (50g) and Mg (9.2 g)] in tetrahydrofuran (500 ml) at -78.deg. C. under N2.. Themixture was stirred for 2 hours at the room temperature and partitioned betweenethyl acetate and water.. The organic layer was washed with 1N-HCl, water, sat.NaHCO3 and brine.. The dried solvent was evaporated in vacuo and the residuewas purified by chromatography on silica gel to give(1R,2S)-1-(4,5-diphenyloxazol-2-yl)-1-hydroxy-2-(3-methoxybenzyl)cyclohexane(29.2 g). IR (Nujol): 3400, 1600 cm-1; NMR (CDCl3): 1.4-2.4 (9H, m), 3.07(1H, d, J=10 Hz), 3.52 (1H, m), 3.74 (3H, s), 6.7-6.9 (4H, m), 7.15 (1H, t, J=8Hz), 7.2-7.8 (10H, m); Mass (m/z): 440 (M+H)+.

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